A conventional conundrum

A developmental conundrum

Wnt signaling orchestrates morphogenetic processes in which changes in gene expression are associated with dramatic changes in cell organization within developing tissue/organs. Upon signaling, excess beta-catenin not utilized at cell-cell junctions becomes stabilized, where it can provide the transcriptional activating domain for Lef/Tcf DNA binding proteins. In skin epithelium, forced stabili...

Xiphodynia: A diagnostic conundrum

This paper presents 3 case reports of xiphodynia that presented to a chiropractic clinic. The paper examines aspects of xiphodynia including relevant anatomy of the xiphoid, as well as the incidence, aetiology, symptoms, diagnosis, and treatment. A brief overview of the mechanism of referred pain is presented.

Solving a Cartesian Conundrum

LIn a recent issue of this journal, Robert Oakes has proposed a “Cartesian conundrum,” arguing that certain elements in Descartes’ philosophical theology are incompatible.^ I believe that this conundrum can be solved. It does, however, lead to an interesting question about what constitutes the “materiality” of a material object. In this article I propose to solve the conun­ drum, and to say a l...

THE CONUNDRUM OF EUTHANASIA

Hemophagocytic Lymphohistiocytosis: A Diagnostic Conundrum

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation causing widespread inflammation and tissue destruction leading to multi-organ dysfunction and failure. Making the diagnosis of HLH could be quite challenging due to the broad range of presenting symptoms and their lack of specificity. After ruling out considerations for differential diagnoses, recognizing the ...